Your technology needs expert development to get to the next stage. We’ve proven our ability to foster growth, advance technology, cultivate progress and keep your project on track. Some examples of products we’ve helped develop include:
Enzyme Replacement Therapy
We developed methods to conjugate a novel drug delivery technology to enzymes to treat enzyme deficiency diseases for a virtual company. Besides developing and optimizing the conjugations, we also stabilized the protein constructs and increased their serum half-life via pegylation. We supported the animal trials of our conjugated enzymes and confirmed target tissue delivery and in vivo activity.
Tumor Targeting and Imaging
Controlling the serum half-life was key for custom Fab molecules and diabodies we produced for use in tumor imaging studies. These antibody fragments were specifically labeled with a collaborator’s proprietary PEGs to precisely regulate the clearance rate in serum. These conjugates were then used for successful tumor imaging studies.
Clinical and POC diagnostics
Finding the right way to label an biologic was key when we helped a client develop a sensitive clinical diagnostic for the flu. We developed a custom labeling method, as the biomolecule lost activity using the client’s normal procedure.
Clinical Cell Biology
Working with a cancer immunotherapy company that created a personalized adoptive cell therapy, our scientists developed a GLP compliant assays to support Phase II clinical trials. These procedures included ex vivo manipulation of patient derived blood cells to measure the production of key cytokines, establishment of cell proliferation assays, performing FACS analysis of cell surface markers, and demonstrating effective tumor cell killing by the client’s novel therapeutic. Our results will be used to support FDA approval and advance the biologic to Phase III clinical trials.
To optimize a cell-free production system, we engineered several folding enhancing chaperone genes into a specific loci on the production strain. Using synthetic DNA, we systematically engineered the strain’s chromosome to deliverer a robust protein production system while producing the required chaperone proteins in specific concentrations.
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